Dendritech, Inc.
SAFETY DATA SHEET
Revision Date: 4June15
________________________________________________________________________________
1. PRODUCT AND COMPANY IDENTIFICATION
1.1 Product identifiers
Product Name
: Polyamidoamine (PAMAM) dendrimer, primary amine surface, aqueous solution
(all generations)
Family Code
: 121
Brand
: Dendritech
1.2 Relevant identified uses of substance or mixture and uses advised against
Identified uses
: Laboratory research chemical, manufacture of substances, no food use
1.3 Supplier Details
Company
: Dendritech, Inc.
3110 Schuette Drive
Midland, Michigan
USA
Telephone: 989-496-2016
Fax: 989-496-2051
1.3 Emergency telephone number
Emergency Number
: CHEMTRECTM 1-800-424-9300 (Outside USA: 703-527-3887)
__________________________________________________________________________________
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
This mixture is not considered hazardous under current GHS guidelines.
Nonhazardous ingredients are polyamidoamine and water.
Not an eye or skin irritant under GHS guidelines..
2.2 GHS Label elements, including precautionary statements
Pictogram: No hazard symbols required
Signal word: No signal word required
Hazard statement(s): None required
Precautionary statement(s)
P281
Use personal protective equipment as required.
P301+312
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P302+352
IF ON SKIN: Wash with soap and water.
P305+351+338
IF IN EYES: Rinse continuously with water for several minutes. Remove contact
lenses if present and easy to do – continue rinsing
P333+313
IF skin irritation or a rash occurs: Get medical advice/attention.
P411+235
Store at temperatures not exceeding 100C/500 F. Keep cool.
P370 + P378
In case of fire: Use water spray, alcohol-resistant foam, dry chemical or carbon
dioxide for extinction..
P501
Dispose of contents/ container to an approved waste disposal plant.
2.3 Hazards not otherwise classified (HNOC) or not covered by GHS – none
___________________________________________________________________________________
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.2 Mixtures
Description
: Polyamidoamine (PAMAM), primary amine surface, aqueous solution.
Molecular Weight
: Variable depending on dendrimer product generation; from 517 to 116,000 MW
Hazardous components: None
Nonhazardous components:
Component
Classification
Concentration
Polyamidamine in water
No acute hazards
5-90 weight%
CAS #93376-66-0
(G2; illustrative for family)
NFPA ratings:
Health 0
Fire 0
Reactivity 0
____________________________________________________________________________________
4. FIRST AID MEASURES
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance. Move out of dangerous
area.
If inhaled
Inhalation is unlikely. If somehow aspirated into lungs, move person into fresh air. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Remove contaminated clothing. Consult a physician if irritation is
present after washing.
In case of eye contact
Flush eyes with water for 15 minutes as a precaution. Consult a physician if irritation is present after
washing.
If swallowed
Consult a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labeling (see section 2.2) and/or in
section 11.
4.3 Indication of any immediate medical attention and special treatment needed
No data available
___________________________________________________________________________________
5. FIREFIGHTING MEASURES
5.1 Extinguishing mediaSuitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Will produce carbon and nitrogen oxides and varied nitrogen-containing products upon combustion.
5.3 Advice for firefighters
Wear self contained breathing apparatus and protective fire clothing.
5.4 Further information
Hazardous polymerization does not occur.
__________________________________________________________________________________
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Wear protective clothing and ensure adequate ventilation when cleaning spills. Gloves (nitrile gloves
preferred) and googles are minimum protective equipment for larger spills.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains, sewers or waterways.
Biodegrades in water.
6.3 Methods and materials for containment and cleaning up
Contain spillage and then collect with an explosion proof vacuum cleaner or pump, or by wet-brushing
and place in container for disposal according to local regulations (see section 13). Small spills can soaked
up in noncombustible absorbent material like sand, silica gel or clay.
6.4 Reference to other sections
For disposal see section 13.
____________________________________________________________________________________
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Minimum personal protective equipment are rubber gloves (nitrile
gloves recommended) and safety glasses. Goggles and impervious clothing should be worn if contact
with large quantities is possible.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Avoid contact with copper and copper-containing alloys.
Avoid contact with strong oxidizing or reducing agents, acids and acid halides (possible reaction hazard).
Recommended storage temperature: 2 - 8 °C for long term storage of dendrimer solutions to maintain
product quality.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
___________________________________________________________________________________
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Components with workplace control parametersPolyamidoamine dendrimers component have no workplace control parameters (e.g. ACGIH, TLV or PEL
limits) established.
Biological occupational exposure limits
None determined.
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the
product.
Personal protective equipment
Eye/face protection
Safety glasses are minimum protection. Use goggles if contact with larger quantities is possible. Use
equipment for eye protection tested and approved under appropriate government standards such as
NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Nitrile rubber gloves are preferred. Gloves must be inspected prior to use. Use proper
glove removal technique (without touching glove's outer surface) to minimize skin contact with this
product. Dispose of contaminated gloves after use in accordance with applicable laws and good
laboratory practices. Wash and dry hands.
Body Protection
Complete suit protecting against chemicals may be required for large quantity handling,
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with
multipurpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to
engineering controls (adequate ventilation).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains or waterways.
_________________________________________________________________________________
9.0 PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
a) Appearance
: Clear yellow liquid
b) Odor
: Essentially odorless
c) Odor Threshold
: Not applicable
d) pH
: 11, approximately
e) Melting point/freezing point
: varies with dendrimer content
f) Initial boiling point
: no data available
g) Flash point
: no data available
h) Evaporation rate
: no data available
i) Flammability (solid, gas):
: no data available
j) Upper/lower flammability limits
: no data available
k)Vapour pressure
: no data available
l) Vapour density
: no data available
m) Relative density
: no data available
n) Water solubility
: highly water soluble
o) Partition coefficient: n-octanol/water : no data available
p) Auto-ignition temperature
: no data available
q) Decomposition temperature
: no data availabler) Viscosity
: no data available.
s) Explosive properties
: no data available
t) Oxidizing properties
: no data available
9.2 Other safety information
No data available
________________________________________________________________________________
10. STABILITY AND REACTIVITY
10.1 Reactivity
Avoid contact with chemicals that can react with amines, as heat and pressure could be generated.
Examples are shown in section 10.5.
10.2 Chemical stability
Stable under recommended storage conditions and normal use conditions.
10.3 Possibility of hazardous reactions
Hazardous polymerization will not occur.
10.4 Conditions to avoid
Extremes of temperature can lead to deterioration in product quality.
10.5 Incompatible materials
Acid chlorides, acid anhydrides, oxidizing agents, alkali metals, reducing agents, acids, reactive
monomers like acrylates. Avoid contact with copper, brass or other copper alloys in piping and containers.
10.6 Hazardous decomposition products
Oxides of carbon and nitrogen can be formed under fire conditions.
In the event of fire: see section 5.
_________________________________________________________________________________
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Polyamidoamine (PAMAM) dendrimers in aqueous solution have generally low acute hazard.
Acute toxicity
(G1 and G5 dendrimers tested)
Oral:
LD50/rat
: > 5000 mg/kg
Inhalation:
LC50/4 h/rat
: Not applicable
Dermal:
LD50/rabbit
: >2000 mg/kg
Inhalation
The polyamidoamine dendrimer has a very high vapor pressure and significant airborne concentrations
are unlikely.
Ingestion
LD50 (rats)
: >5000 mg/kg.
Not considered acutely toxic.
Skin corrosion/irritationNot considered a skin irritant.
Serious eye damage/eye irritation
Essentially non-irritating to the eyes.
Respiratory or skin sensitization
(G2 dendrimer tested)
Buehler tests (guinea pig) indicated a G2 dendrimer neutralized to pH=7 was not a skin sensitizer.
Germ cell mutagenicity
Was not a mutagen by Ames bacterial testing to several Salmonella typhimurium tester strains.
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
No information.
Teratogenicity
No information.
Specific target organ toxicity - single exposure
None observed.
Specific target organ toxicity - repeated exposure
No information.
Aspiration hazard
Minimal due to low vapor pressure. Sticky, very viscous liquid when dry. No particulates.
Additional Information
None.
__________________________________________________________________________________
12. ECOLOGICAL INFORMATION
12.1 Toxicity
Not determined.
12.2 Persistence and degradability
Readily biodegradable; completely miscible with water
12.3 Bioaccumulative potential
Not expected to bioaccumulate due to high water solubility.
12.4 Mobility in soil
Will tend to accumulate in soil pore water.12.5 Results of PBT and vPvB assessment
Would not be expected to be persistent or bioaccumulating. Toxicity could be similar to other polyamines.
12.6 Other adverse effects
None known
____________________________________________________________________________________
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non
recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal
service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
____________________________________________________________________________________
14. TRANSPORT INFORMATION
There are no specific transportation requirements (e.g. UN number or packing group) under DOT (US),
IMDG or IATA.
___________________________________________________________________________________
15. REGULATORY INFORMATION
Labelling according to EC Directives
None
SARA 302 Components
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 313.
SARA 311/312 Hazards
None
Pennsylvania Right To Know Components
None
New Jersey Right To Know Components
None
California Prop. 65 Components
Does not contain any chemical known to the State of California to cause birth defects or other
reproductive harm.
___________________________________________________________________________________
16. OTHER INFORMATION
NFPA Rating
Health hazard:
0
Fire Hazard:
0
Reactivity Hazard:
0Further information
Copyright 2015 Dendritech, Inc. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used
only as a guide by a properly trained person using this product. The information in this document is based
on the present state of our knowledge and is applicable to the product only with regard to appropriate
safety precautions. It does not represent any guarantee of the properties of the product. Dendritech, Inc.
shall not be held liable for any damage resulting from handling or from contact with the above product.
See www.dendritech.com for more information on products and conditions of sale.
Preparation Information
Dendritech, Inc.
